Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype
Identifieur interne : 001101 ( Main/Exploration ); précédent : 001100; suivant : 001102Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype
Auteurs : Carmine Vitale [Italie] ; Vincenzo Marcelli [Italie] ; Roberto Allocca [Italie] ; Gabriella Santangelo [Italie] ; Pasquale Riccardi [Italie] ; Roberto Erro [Italie] ; Marianna Amboni [Italie] ; Maria Teresa Pellecchia [Italie] ; Autilia Cozzolino [Italie] ; Katia Longo [Italie] ; Marina Picillo [Italie] ; Marcello Moccia [Italie] ; Valeria Agosti [Italie] ; G. Sorrentino [Italie] ; Michele Cavaliere [Italie] ; Elio Marciano [Italie] ; Paolo Barone [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%], χ2 = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ2 = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis.
Affiliations:
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Sorrentino</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cavaliere, Michele" sort="Cavaliere, Michele" uniqKey="Cavaliere M" first="Michele" last="Cavaliere">Michele Cavaliere</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Otolaryngology, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>15 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type="wicri:Area/Main/Exploration">001101</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype</title><author><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Marcelli, Vincenzo" sort="Marcelli, Vincenzo" uniqKey="Marcelli V" first="Vincenzo" last="Marcelli">Vincenzo Marcelli</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Allocca, Roberto" sort="Allocca, Roberto" uniqKey="Allocca R" first="Roberto" last="Allocca">Roberto Allocca</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" 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aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Erro, Roberto" sort="Erro, Roberto" uniqKey="Erro R" first="Roberto" last="Erro">Roberto Erro</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 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Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neurodegenerative Diseases Center, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Salerno</wicri:noRegion></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Moccia, Marcello" sort="Moccia, Marcello" uniqKey="Moccia M" first="Marcello" last="Moccia">Marcello Moccia</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Agosti, Valeria" sort="Agosti, Valeria" uniqKey="Agosti V" first="Valeria" last="Agosti">Valeria Agosti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Sorrentino, G" sort="Sorrentino, G" uniqKey="Sorrentino G" first="G." last="Sorrentino">G. Sorrentino</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cavaliere, Michele" sort="Cavaliere, Michele" uniqKey="Cavaliere M" first="Michele" last="Cavaliere">Michele Cavaliere</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Otolaryngology, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>15 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Marciano, Elio" sort="Marciano, Elio" uniqKey="Marciano E" first="Elio" last="Marciano">Elio Marciano</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neurodegenerative Diseases Center, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Salerno</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Audiometry</term><term>Auditory disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Phenotype</term><term>Pure tone</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble de l'audition</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Phénotype</term><term>Son pur</term><term>Audiométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%],<sub> </sub>χ<sup>2</sup> = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ<sup>2</sup> = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name></noRegion><name sortKey="Agosti, Valeria" sort="Agosti, Valeria" uniqKey="Agosti V" first="Valeria" last="Agosti">Valeria Agosti</name><name sortKey="Agosti, Valeria" sort="Agosti, Valeria" uniqKey="Agosti V" first="Valeria" last="Agosti">Valeria Agosti</name><name sortKey="Allocca, Roberto" sort="Allocca, Roberto" uniqKey="Allocca R" first="Roberto" last="Allocca">Roberto Allocca</name><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Cavaliere, Michele" sort="Cavaliere, Michele" uniqKey="Cavaliere M" first="Michele" last="Cavaliere">Michele Cavaliere</name><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><name sortKey="Erro, Roberto" sort="Erro, Roberto" uniqKey="Erro R" first="Roberto" last="Erro">Roberto Erro</name><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><name sortKey="Marcelli, Vincenzo" sort="Marcelli, Vincenzo" uniqKey="Marcelli V" first="Vincenzo" last="Marcelli">Vincenzo Marcelli</name><name sortKey="Marciano, Elio" sort="Marciano, Elio" uniqKey="Marciano E" first="Elio" last="Marciano">Elio Marciano</name><name sortKey="Moccia, Marcello" sort="Moccia, Marcello" uniqKey="Moccia M" first="Marcello" last="Moccia">Marcello Moccia</name><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><name sortKey="Riccardi, Pasquale" sort="Riccardi, Pasquale" uniqKey="Riccardi P" first="Pasquale" last="Riccardi">Pasquale Riccardi</name><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><name sortKey="Sorrentino, G" sort="Sorrentino, G" uniqKey="Sorrentino G" first="G." last="Sorrentino">G. Sorrentino</name><name sortKey="Sorrentino, G" sort="Sorrentino, G" uniqKey="Sorrentino G" first="G." last="Sorrentino">G. Sorrentino</name><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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